September 14, 2018
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Stanton L. Gerson, MD has been director of the Case Comprehensive Cancer Center since 2003. Dr. Gerson is also the Asa and Patricia Shiverick- Jane Shiverick (Tripp) Professor of Hematological Oncology and founding director of the Ohio Wright Center for Stem Cell and Regenerative Medicine, now called the National Center for Regenerative Medicine.
Dr. Gerson's research interests are in the areas of stem cells and DNA repair. In his stem cell research, he developed mesenchymal stem cells as a therapeutic infusion for blood stem cell transplantation and for the correction of genetic disorders. This therapy is approaching FDA approval. He identified a gene therapy strategy method that creates drug resistant stem cells capable of selectively repopulating the recipient without the need for high dose toxic therapy. This strategy is now used experimentally and clinically throughout the country. In the area of DNA repair, he developed inhibitors of DNA repair to improve the efficacy of anti-cancer agents. Both are currently in clinical trials. Finally, Dr. Gerson has developed transgenic mouse models that examine the role of critical genes in the stability of stem cell populations over the lifetime of the animal. These studies may predict stem cell diseases of aging and cancer. His research has generated 12 patents in the area of gene therapy and cancer drug development that have been licensed to three companies.
His leadership of the Stem Cell Center and the Cancer Center involve coordinating research throughout the medical centers in Cleveland. He also led University Hospitals' effort to bring cancer care under one roof in the new cancer hospital that opened spring 2011.
Dr. Gerson is also is director of the Seidman Cancer Center and the National Center for Regenerative Medicine.