Bruce J. Aronow, PhD

Bruce J. Aronow, PhD

Dr. Aronow is a computational geneticist and developmental biologist. His group carries out analyses of many different kinds of data, develops algorithms, and builds websites and databases. These tools allow researchers from varying disciplines and backgrounds to analyze genetic and genomic data—either their own or that gathered from published sources—to better understand, model, and carry out new research about normal development and disease. His group is highly collaborative with clinical and basic researchers across a broad range of research projects encompassing many areas of biology and disease, including normal and abnormal development, in vivo and in vitro disease models, and large-scale clinical studies. 

Data of interest includes genetic, genomic, proteomic, metabolomic, imaging, and therapeutic agent response measures. Recent areas of interest include large-scale clinical sample analyses, single cell-based dissection of developmental and disease tissues, and in vitro stem cell-based modeling of normal and disease-affected tissues including abnormal neurological, immunological, cardiac, and cancer tissues. 

The lab’s recent efforts focus on predicting new therapeutic approaches based on disease mechanisms in the areas of inflammatory bowel disease, eosinophilic esophagitis, sickle cell anemia, cardiac development, and neurological and psychiatric diseases. His group is working on efforts to define the transcriptome of the developing kidney, lung and brain. They are using stem cell-derived cells and organoids to dissect mechanisms that underlie organ development and function as well as oncogenesis. They are also working to infer novel disease indications for known drugs by semantically linking drug action and disease mechanism relationships.