NCI’s CPTAC Releases an Openly Accessible Data Set Primed for Multi-omic Integration

March 29, 2014

On September 4, 2013, NCI’s Clinical Proteomics Tumor Analysis Consortium (CPTAC) publicly released proteomic data produced from colorectal tumor samples previously analyzed as part ofThe Cancer Genome Atlas (TCGA) initiative.  This is the first release of proteomic tumor data designed to complement genomic data from the same tumors.

Since its launch in 2006, the Consortium has “aimed at improving proteomic analysis platforms to reliably identify, quantify, and compare proteins and peptides in complex biological mixtures.”  After five years of technology development, inter-laboratory studies, and statistical analyses of variation, the program entered a second phase, this time focused on data production.  CPTAC obtained access to a subset of tumors analyzed by TCGA, with a view toward generating proteomic data sets to enable integration with the genomic data.

The CPTAC consists of five teams that create a network of Proteome Characterization Centers (PCCs):

  • Broad Institute; Fred Hutchinson Cancer Research Center
  • Johns Hopkins University
  • Pacific Northwest National Laboratory
  • Vanderbilt University
  • Washington University; University of North Carolina, Chapel Hill