Analysis and Visualization of Longitudinal Genomic and Clinical Data from the AACR Project GENIE Biopharma Collaborative in cBioPortal
International cancer registries make real-world genomic and clinical data available, but their joint analysis remains a challenge. AACR Project GENIE, an international cancer registry collecting data from 19 cancer centers, makes data from >130,000 patients publicly available through the cBioPortal for Cancer Genomics (https://genie.cbioportal.org). For 25,000 patients, additional real-world longitudinal clinical data, including treatment and outcome data, are being collected by the AACR Project GENIE Biopharma Collaborative using the PRISSMM data curation model. Several thousand of these cases are now also available in cBioPortal. We have significantly enhanced the functionalities of cBioPortal to support the visualization and analysis of this rich clinico-genomic linked dataset, as well as datasets generated by other centers and consortia. Examples of these enhancements include (i) visualization of the longitudinal clinical and genomic data at the patient level, including timelines for diagnoses, treatments, and outcomes; (ii) the ability to select samples based on treatment status, facilitating a comparison of molecular and clinical attributes between samples before and after a specific treatment; and (iii) survival analysis estimates based on individual treatment regimens received. Together, these features provide cBioPortal users with a toolkit to interactively investigate complex clinico-genomic data to generate hypotheses and make discoveries about the impact of specific genomic variants on prognosis and therapeutic sensitivities in cancer.
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Press Release November 2025: Oracle and Ci4CC Partner to Accelerate Oncology Innovation Strategic collaboration to leverage Ci4CC’s national network and Oracle’s technology to help advance AI in oncology, EHR interoperability, next-gen clinical trials, and personalized medicine 24th Cancer Center Informatics Society Symposium - MIAMI BEACH, Florida – November 7, 2025 – Oracle Health and Life Sciences and the Cancer Center Informatics Society (Ci4CC), a nonprofit uniting cancer centers, researchers, and industry innovators, are collaborating to advance AI innovation in oncology care and research. The collaboration aims to bring together Oracle’s technology with Ci4CC’s Initiatives Program and national network of NCI-Designated and Community Care Cancer Centers. The two organizations plan to collaborate to design an EHR optimized for cancer care. “Cancer remains a leading cause of death worldwide, but AI and data science have become powerful allies in the fight,” said Seema Verma, executive vice president and general manager, Oracle Health and Life Sciences. “Combining Ci4CC’s unparalleled expertise and network with our state-of-the-art proven AI-powered healthcare applications, we have the opportunity to accelerate discoveries that can help cure cancer.” The strategic collaboration intends to develop initiatives across oncology care and clinical research. This includes integrating clinical and genomic data for personalized medicine solutions, pioneering AI-driven approaches for clinical trial innovation and drug development, establishing robust real-world evidence frameworks, and advancing precision oncology platforms. “This alliance with Oracle marks a significant milestone for Ci4CC and our mission to further cancer informatics,” said Sorena Nadaf-Rahrov, MS, MMI, PhDc, President & CEO - Cancer Center Informatics Society. “Advancements in cancer research and clinical care are not achieved in isolation. That’s why fostering such collaborative networks is fundamental to our Initiatives Program, and central to the Society’s mission. By integrating Oracle’s cutting-edge and AI-enabled technology with real-world data from our national network of NCI-Designated and Community Cancer Centers, we hope to incubate and operationalize initiatives that will redefine cancer research and patient care. Turning data into knowledge, and knowledge into health continues to drive the Cancer Center Informatics Society forward.” Oracle NewsRoom: https://www.oracle.com/news/announcement/oracle-and-ci4cc-partner-to-accelerate-oncology-innovation-2025-11-07/ PR Newswire: https://www.prnewswire.com/news-releases/oracle-and-ci4cc-partner-to-accelerate-oncology-innovation-302608712.html
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With heavy hearts, we remember and honor Brady Davis, whose sudden passing leaves an immense void. Brady was a devoted supporter and invaluable contributor to the Cancer Center Informatics Society, dedicating countless hours to advancing our mission and strengthening our community. His expertise, enthusiasm, and unwavering commitment shaped our initiatives and inspired everyone fortunate enough to work alongside him. Brady’s legacy will live on through the progress he championed and the connections he fostered. We extend our deepest sympathies to his family, friends, and all who knew him. He will be greatly missed. In honor of Brady’s legacy, Ci4CC will be forming a committee to explore meaningful ways to memorialize him within our society for years to come. We plan to announce the committee’s recommendations at our Spring Summit in San Diego, CA, on March 31, 2025. Please find his obituary here , and visit his memorial page on MyKeeper to leave a tribute. Support the Davis family in Brady’s memory via GoFundMe ---------- Cancer Center Informatics Society (Ci4CC) Sorena Nadaf-Rahrov & Warren Kibbe Co-Founders, Ci4CC
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