Eric W. Klee, PhD

Eric W. Klee, Ph.D., is a consultant in the Division of Computational Biology, Department of Quantitative Health Sciences, with joint appointments in the Department of Clinical Genomics and in the Department of Laboratory Medicine and Pathology.

Dr. Klee is the William O. Lund, Jr. and Natalie C. Lund Program Director for Clinomics, Center for Individualized Medicine. He is also the Enterprise Co-Director of Data Science and Informatics for the Mayo Clinic Comprehensive Cancer Center, and the Midwest Associate Director of Research and Innovation for the Mayo Clinic Center for Individualized Medicine. Additionally, he has leadership roles in Bioinformatics, Translational Omics Program, and Omics Data Platform Strategic Initiative within Mayo Clinic’s Center for Individualized Medicine, and the Advanced Diagnostics Laboratory at Mayo Clinic. Dr. Klee holds the academic rank of Associate Professor of Biomedical Informatics, Mayo Clinic College of Medicine. He joined the staff of Mayo Clinic in 2005.

Dr. Klee earned his B.S. in electrical engineering at Iowa State University followed by his M.S. and Ph.D. in health informatics at the University of Minnesota.

Dr. Klee’s research focuses on the use of omic technologies for research and clinical testing. He has developed a translational research program focused on rare or undiagnosed Mendelian disease, applying cutting-edge technologies to seek diagnoses and/or treatments for patients where current state-of-the-art clinical testing is indeterminant. He has active translational research in hereditary cancer and the creation of systems to support the rapid interpretation and dissemination of genomic results in population level studies. His research uses integrative omics and functional studies to better characterize the putative role of variants of uncertain significance in the context of patient-specific disease state. Dr. Klee is also actively engaged in leading the Mayo Clinic Omics Data Platform as part of the digitization of practice activities at Mayo Clinic, designing the next generation of analytic resources to support Mayo’s translational omic activities. He engages in development and implementation of systems to support sequence analysis and interpretation in the context of individualized precision medicine.

Dr. Klee is frequently invited to give presentations on his research to both national and international audiences. He consistently publishes in high-impact scientific journals and has authored over 200 peer reviewed articles, in addition to abstracts and other written publications. He also serves on the editorial board for Cold Spring Harbor Molecular Case Studies.

In recognition of his work, Dr. Klee received the National Academy of Clinical Biochemistry Distinguished Abstract Award, and he was selected for the KL2 Mentored Career Development Program through the Mayo Clinic Center for Translational Science Activities.